PREPARATION AND IN-VITRO ACTIVITY OF ARYL ETHER DERIVATIVES OF THE FK-506 RELATED IMMUNOSUPPRESSIVE MACROLIDES ASCOMYCIN AND L-683,742

被引：29

作者：

SINCLAIR, PJ ^{[1
]}

WONG, F ^{[1
]}

WYVRATT, M ^{[1
]}

STARUCH, MJ ^{[1
]}

DUMONT, F ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT IMMUNOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/0960-894X(95)00161-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The arylation of the immunosuppressive macrolides ascomycin and L-683,742 using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported.

引用

页码：1035 / 1038

页数：4

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