STOPPED-FLOW ESR STUDY ON THE REACTIVITY OF VITAMIN-E, VITAMIN-C AND ITS LIPOPHILIC DERIVATIVES TOWARDS FREMYS SALT IN MICELLAR SYSTEMS

被引：19

作者：

LIU, ZL

HAN, ZX

CHEN, P

LIU, YC

机构：

[1] National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1990年 / 56卷 / 01期

基金：

中国国家自然科学基金;

关键词：

antioxidant reactivity; ESR; micellar effect; vitamin C; vitamin E;

D O I：

10.1016/0009-3084(90)90090-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction between Fremy's salt and α-tocopherol (VE), ascorbic acid (VC) and its lipophilic derivatives ascorbyl-6-caprylate (VC-8), 6-laurate (VC-12) and 6-palmitate (VC-16) were studied by stopped-flow ESR spectroscopy in cetyl trimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) micelles, as a model reaction of these antioxidants with alkyl peroxy radicals in biological systems. The second order rate constants for the reaction of Fremy's salt with VE in CTAB and SDS micelles were found to be 7.9 × 103 and 2.2 M-1 s-1, respectively, with as high as a 3600-fold variation. Rate constants for VC, VC-8, VC-12 and VC-16 are 4.3, 35, 53 and 56 × 103 M-1 s-1 and 3.3, 2.7, 1.2 and 0.86 × 103 M-1 s-1 in CTAB and SDS micelles, respectively. The results demonstrate remarkable effects of the charge type of the micelles and the side-chain of the antioxidants on the antioxidation reactivity in the micelles. It reveals that the inter-micellar diffusion may be the rate-limiting step for antioxidation carried out in micelles. © 1990.

引用

页码：73 / 80

页数：8

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