GLOMERULAR-FILTRATION RATE AND ELECTROLYTE HANDLING IN RESPONSE TO SODIUM LOADING AND DEPLETION - A TWIN STUDY

被引：8

作者：

GRIM, CE ^{[1
]}

MILLER, JZ ^{[1
]}

CHRISTIAN, JC ^{[1
]}

机构：

[1] INDIANA UNIV,SCH MED,DEPT MED GENET,INDIANAPOLIS,IN 46202

来源：

ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE | 1979年 / 28卷 / 02期

关键词：

D O I：

10.1017/S0001566000009181

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Possible genetic influences on glomerular filtration rate and electrolyte excretion were investigated in 55 (37 monozygotic, 18 dizygotic) young adult white twin pairs. Subjects were studied during a five-day hospitalization involving sodium loading and sodium depletion. No evidence of genetic variability was found in the control levels of serum or urine sodium and potassium. Following a saline infusion it was possible to detect genetic influence in electrolyte handling. Creatinine clearance, used as a measure of glomerular filtration rate, did not appear to be genetically mediated. The results indicate that genetic factors are important in sodium handling in normal individuals and that this is independent of glomerular filtration rate.

引用

页码：149 / 154

页数：6

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