THE DISCOVERY OF A NOVEL CALCIUM-CHANNEL BLOCKER RELATED TO THE STRUCTURE OF POTASSIUM CHANNEL OPENER CROMAKALIM

被引：11

作者：

ATWAL, KS

MCCULLOUGH, JR

HEDBERG, A

CONDER, ML

AHMED, SZ

CUCINOTTA, G

NORMANDIN, DE

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80411-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

During our studies aimed at the identification of novel analogs of the potassium channel opener cromakalim (3), we serendipitously observed pyranoquinoline 4 to possess pure calcium channel blocking activity. The results of the studies conducted to confirm the calcium channel blocking mechanism of 4 are reported in this paper.

引用

页码：1475 / 1478

页数：4

共 19 条

[1] ARYL CYANOGUANIDINE POTASSIUM CHANNEL OPENERS
ATWAL, KS
MORELAND, S
MCCULLOUGH, JR
OREILLY, BC
AHMED, SZ
NORMANDIN, DE
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (01) : 83 - 86
[2] HIGH-AFFINITY BINDING OF A CALCIUM-CHANNEL ANTAGONIST TO SMOOTH AND CARDIAC-MUSCLE
BOLGER, GT
GENGO, PJ
LUCHOWSKI, EM
SIEGEL, H
TRIGGLE, DJ
JANIS, RA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 104 (04) : 1604 - 1609
[3] BLOCK OF SODIUM CURRENTS BY THE CALCIUM ANTAGONIST-D600 IN HUMAN-HEART CELL SEGMENTS
BUSTAMANTE, JO
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1985, 403 (02): : 225 - 227
[4] STRUCTURE AND FUNCTION OF VOLTAGE-SENSITIVE ION CHANNELS
CATTERALL, WA
[J]. SCIENCE, 1988, 242 (4875) : 50 - 61
[5] SPECIFICITY OF ACTION OF THE NOVEL ANTIHYPERTENSIVE AGENT, BRL-34915, AS A POTASSIUM CHANNEL ACTIVATOR - COMPARISON WITH NICORANDIL
COLDWELL, MC
HOWLETT, DR
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (21) : 3663 - 3669
[6] de Groot A., 1975, TETRAHEDRON LETT, V39, P3407, DOI 10.1016/S0040-4039(00)91410-2
[7] EVANS JM, 1991, CHEM BRIT, P439
[8] EFFECTS OF VARIOUS ANTIANGINAL DRUGS ON SODIUM INFLUX IN RAT-BRAIN SYNAPTOSOMES AND IN RAT-HEART MUSCLE-CELLS IN CULTURE
GRIMA, M
FREYSSBEGUIN, M
MILLANVOYEVANBRUSSEL, E
DECKER, N
SCHWARTZ, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (01) : 1 - 8
[9] ANTIANGINAL ARYLALKYLAMINES AND SODIUM-CHANNELS - [H-3] BATRACHOTOXININ-A 20-ALPHA-BENZOATE AND [H-3] TETRACAINE BINDING
GRIMA, M
SCHWARTZ, J
SPACH, MO
VELLY, J
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (04) : 641 - 646
[10] ADRENOCEPTOR-MEDIATED CHANGES OF EXCITATION AND CONTRACTION IN VENTRICULAR HEART-MUSCLE FROM GUINEA-PIGS AND RABBITS
HESCHELER, J
NAWRATH, H
TANG, M
TRAUTWEIN, W
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1988, 397 : 657 - 670

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