DITERPENES FROM ARNICA-ANGUSTIFOLIA

被引：15

作者：

SCHMIDT, TJ ^{[1
]}

PASSREITER, CM ^{[1
]}

WENDISCH, D ^{[1
]}

WILLUHN, G ^{[1
]}

机构：

[1] BAYER AG,ZF-D-STRUKT FORSCH ABT,D-51368 LEVERKUSEN,GERMANY

来源：

PHYTOCHEMISTRY | 1995年 / 40卷 / 04期

关键词：

ARNICA ANGUSTIFOLIA SSP ATTENUATA; A-MONTANA; ASTERACEAE; DITERPENES; LABDANES; LABD-13(Z)-ENE-8-ALPHA; 15-DIOL; (13R,14R)8,13-EPOXYLABDANE-14,15-DIOL; 8-ALPHA-HYDROXYLABD-13(Z)-ENE-15-AL; 8-ALPHA-HYDROXYLABD-13(E)-ENE-15-AL; 8,13-EPOXYLABDANE-L5-AL; 13,14,15,16-TETRANORLABDANE-12,8-OLIDE (NORAMBREINOLIDE);

D O I：

10.1016/0031-9422(95)00304-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From flowerheads of Arnica angustifolia ssp. attenuata the labdane diterpenes labd-13(Z)-ene-8 alpha, 15-diol (main component) and (13R,14R)8,13-epoxylabdane-14,15-diol were isolated and their structures established by extensive NMR and MS measurements. Both compounds are reported as natural products for the first time. Oxidative degradation of the main component was observed and the oxidation products 8 alpha-hydroxylabd-13(Z)-ene-15-al, 8 alpha-hydroxylabd-13(E)-ene-15-al and 8,13-epoxylabdane-15-al were identified. Additionally, the tetranoriabdanolide norambreinolide, most probably also derived from the labdanes, was detected in minor amounts. A search for diterpenes in flowers of A. montana revealed the presence of small amounts of labd-13(Z)-ene-8 alpha,15-diol.

引用

页码：1213 / 1218

页数：6

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