PFCRK-1, A DEVELOPMENTALLY-REGULATED CDC2-RELATED PROTEIN-KINASE OF PLASMODIUM-FALCIPARUM

被引：62

作者：

DOERIG, C

HORROCKS, P

COYLE, J

CARLTON, J

SULTAN, A

ARNOT, D

CARTER, R

机构：

[1] UNIV EDINBURGH, INST CELL ANIM & POPULAT BIOL, EDINBURGH EH9 3JT, MIDLOTHIAN, SCOTLAND

[2] UNIV EDINBURGH, M INST CELL & MOLEC BIOL, EDINBURGH EH9 3JT, MIDLOTHIAN, SCOTLAND

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1995年 / 70卷 / 1-2期

基金：

英国惠康基金;

关键词：

PLASMODIUM FALCIPARUM; SEXUAL DIFFERENTIATION; PROTEIN KINASE; P58; CELL-CYCLE CONTROL;

D O I：

10.1016/0166-6851(95)00033-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58(GTA) gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

引用

页码：167 / 174

页数：8

共 42 条

[1] SEXUAL-DIFFERENTIATION IN MALARIA PARASITES [J].