EFFECTS OF BORDETELLA-BRONCHISEPTICA DERMONECROTIZING TOXIN ON BONE-FORMATION IN CALVARIA OF NEONATAL RATS

被引：17

作者：

HORIGUCHI, Y ^{[1
]}

OKADA, T ^{[1
]}

SUGIMOTO, N ^{[1
]}

MORIKAWA, Y ^{[1
]}

KATAHIRA, J ^{[1
]}

MATSUDA, M ^{[1
]}

机构：

[1] UNIV OSAKA PREFECTURE,COLL AGR,DEPT VET ANAT,SAKAI,OSAKA 593,JAPAN

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1995年 / 12卷 / 01期

关键词：

BORDETELLA BRONCHISEPTICA; DERMONECROTIZING TOXIN; BONE FORMATION; HISTOMORPHOMETRY;

D O I：

10.1111/j.1574-695X.1995.tb00170.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of Bordetella bronchiseptica dermonecrotizing toxin on bone formation were investigated using a purified toxin preparation. Single injection of 4.3 ng of the toxin into the subcutaneous tissue overlying the calvariae of neonatal rats necrotized periosteum of parietal bone and degenerated osteoblasts within two days. Nine days after the injection, the lesion of the bone tissue became severe; the bone matrix became thin and fragmented. These observations indicate that dermonecrotizing toxin without other factors produced by the organisms impairs bone formation.

引用

页码：29 / 32

页数：4

共 14 条

[1] EFFECTS OF INTERLEUKIN-1 ON BONE TURNOVER IN NORMAL MICE [J].

BOYCE, BF ;

AUFDEMORTE, TB ;

GARRETT, IR ;

YATES, AJP ;

MUNDY, GR .

ENDOCRINOLOGY, 1989, 125 (03) :1142-1150

[2]

ELIAS B, 1990, JPN J VET SCI, V52, P677

[3]

FETTER AW, 1971, LAB INVEST, V24, P392

[4]

FETTER AW, 1975, AM J VET RES, V36, P15

[5]

HANADA M, 1979, JPN J VET SCI, V41, P1

[6] EFFECTS OF BORDETELLA-BRONCHISEPTICA DERMONECROTIC TOXIN ON THE STRUCTURE AND FUNCTION OF OSTEOBLASTIC CLONE MC3T3-E1 CELLS [J].

HORIGUCHI, Y ;

NAKAI, T ;

KUME, K .

INFECTION AND IMMUNITY, 1991, 59 (03) :1112-1116

[7]

HORIGUCHI Y, 1990, FEMS MICROBIOL LETT, V66, P39, DOI 10.1111/j.1574-6968.1990.tb03969.x

[8]

HORIGUCHI Y, 1992, FEMS MICROBIOL LETT, V90, P229, DOI 10.1111/j.1574-6968.1992.tb05157.x

[9] PURIFICATION AND CHARACTERIZATION OF BORDETELLA-BRONCHISEPTICA DERMONECROTIC TOXIN [J].

HORIGUCHI, Y ;

NAKAI, T ;

KUME, K .

MICROBIAL PATHOGENESIS, 1989, 6 (05) :361-368

[10] STIMULATION OF BONE-RESORPTION BY INFLAMED NASAL-MUCOSA, DERMONECROTIC TOXIN-CONTAINING CONDITIONED MEDIUM FROM PASTEURELLA-MULTOCIDA, AND PURIFIED DERMONECROTIC TOXIN FROM PASTEURELLA-MULTOCIDA [J].

KIMMAN, TG ;

LOWIK, CWGM ;

VANDEWEEPALS, LJA ;

THESINGH, CW ;

DEFIZE, P ;

KAMP, EM ;

BIJVOET, OLM .

INFECTION AND IMMUNITY, 1987, 55 (09) :2110-2116

← 1 2 →