REGULATION OF THE EXPRESSION OF THE RAT ANGIOTENSIN-II RECEPTOR MESSENGER-RNA

被引：98

作者：

IWAI, N

INAGAMI, T

机构：

[1] Department of Biochemistry, Vanderbilt University School of Medicine, Nashville

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91844-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of the expression levels of the rat angiotensin II receptor mRNA in the adrenal, aorta, kidney, and brain was assessed by the competitive polymerase chain reaction method. The bilateral nephrectomy or the administration of Dup753 markedly reduced the expression levels of this receptor mRNA in the adrenal and brain stem, but not in the kidney nor aorta. A continuous infusion of angiotensin II increased the expression level of this receptor mRNA in the adrenal but not in the other tissues. It is suggested that the expression level of this receptor mRNA in the adrenal is dependent on the renin angiotensin aldosterone system. © 1992.

引用

页码：1094 / 1099

页数：6

共 6 条

[1]

[Anonymous], 1956, NONPARAMETRIC STAT B

[2] RAT ANGIOTENSIN-II RECEPTOR - CDNA SEQUENCE AND REGULATION OF THE GENE-EXPRESSION [J].