THE REGULATION OF GENE-EXPRESSION BY INSULIN IS DIFFERENTIALLY IMPAIRED IN THE LIVER OF THE GENETICALLY OBESE-HYPERGLYCEMIC WISTAR FATTY RAT

被引：23

作者：

NOGUCHI, T ^{[1
]}

MATSUDA, T ^{[1
]}

TOMARI, Y ^{[1
]}

YAMADA, K ^{[1
]}

IMAI, E ^{[1
]}

WANG, Z ^{[1
]}

IKEDA, H ^{[1
]}

TANAKA, T ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,PHARMACEUT RES LABS 2,OSAKA 532,JAPAN

来源：

FEBS LETTERS | 1993年 / 328卷 / 1-2期

关键词：

L-TYPE PYRUVATE KINASE; GLUCOKINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE; NON-INSULIN-DEPENDENT DIABETES-MELLITUS; INSULIN;

D O I：

10.1016/0014-5793(93)80982-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation by insulin and carbohydrates of the gene expression of three key enzymes involved in glucose metabolism was studied in the liver of the Wistar fatty rat, a model of obese non-insulin-dependent diabetes mellitus. A high glucose or fructose diet, or insulin administration caused a similar magnitude of increase in the level of L-type pyruvate kinase mRNA in the liver of Wistar fatty rats and their lean littermates. However, the induction of glucokinase mRNA and repression of phosphoenolpyruvate carboxykinase mRNA by dietary glucose or insulin were impaired in the fatty rats, whereas fructose caused a similar decrease in phosphoenolpyruvate carboxykinase mRNA in both types of rats. These results indicate that the regulation of gene expression of glucokinase and phosphoenolpyruvate carboxykinase, but not of L-type pyruvate kinase, by insulin is impaired in the liver of the Wistar fatty rat.

引用

页码：145 / 148

页数：4

共 21 条

[11]

IWANISHI M, 1990, DIABETES, V39, pA119

[12] REGULATION OF L-TYPE PYRUVATE-KINASE GENE-EXPRESSION BY DIETARY FRUCTOSE IN NORMAL AND DIABETIC RATS [J].

MATSUDA, T ;

NOGUCHI, T ;

TAKENAKA, M ;

YAMADA, K ;

TANAKA, T .

JOURNAL OF BIOCHEMISTRY, 1990, 107 (04) :655-660

[13] REGULATION OF THE GENE-EXPRESSION OF GLUCOKINASE AND L-TYPE PYRUVATE-KINASE IN PRIMARY CULTURES OF RAT HEPATOCYTES BY HORMONES AND CARBOHYDRATES [J].

MATSUDA, T ;

NOGUCHI, T ;

YAMADA, K ;

TAKENAKA, M ;

TANAKA, T .

JOURNAL OF BIOCHEMISTRY, 1990, 108 (05) :778-784

[14]

MUNNICH A, 1987, J BIOL CHEM, V262, P17065

[15] AN ENHANCER UNIT OF L-TYPE PYRUVATE-KINASE GENE IS RESPONSIBLE FOR TRANSCRIPTIONAL STIMULATION BY DIETARY FRUCTOSE AS WELL AS GLUCOSE IN TRANSGENIC MICE [J].

NOGUCHI, T ;

OKABE, M ;

WANG, ZY ;

YAMADA, K ;

IMAI, E ;

TANAKA, T .

FEBS LETTERS, 1993, 318 (03) :269-272

[16]

NOGUCHI T, 1982, EUR J BIOCHEM, V128, P583

[17]

NOGUCHI T, 1985, J BIOL CHEM, V260, P4393

[18]

NOGUCHI T, 1993, NUTR GENE EXPRESSION, P169

[19] HEPATIC GLUCONEOGENESIS GLYCOLYSIS - REGULATION AND STRUCTURE-FUNCTION-RELATIONSHIPS OF SUBSTRATE CYCLE ENZYMES [J].

PILKIS, SJ ;

CLAUS, TH .

ANNUAL REVIEW OF NUTRITION, 1991, 11 :465-515

[20] MOLECULAR PHYSIOLOGY OF THE REGULATION OF HEPATIC GLUCONEOGENESIS AND GLYCOLYSIS [J].

PILKIS, SJ ;

GRANNER, DK .

ANNUAL REVIEW OF PHYSIOLOGY, 1992, 54 :885-909

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