PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .1. PRODUCTION, ISOLATION, AND BIOLOGICAL PROPERTIES

被引：114

作者：

TOMODA, H ^{[1
]}

KIM, YK ^{[1
]}

NISHIDA, H ^{[1
]}

MASUMA, R ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 02期

关键词：

D O I：

10.7164/antibiotics.47.148

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aspergillus fumigatus FO-1289, a soil isolate, was found to produce a series of novel inhibitors of acyl-CoA: cholesterol acyltansferase (ACAT). Four active compounds, named pyripyropenes A, B, C and D, were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography, ODS column chromatography and preparative HPLC. Pyripyropenes A, B, C and D show very potent ACAT inhibitory activity in an enzyme assay system using rat liver microsomes with IC50 values of 58, 117, 53 and 268 nM, respectively.

引用

页码：148 / 153

页数：6

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