PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .2. STRUCTURE ELUCIDATION OF PYRIPYROPENE-A, PYRIPYROPENE-B, PYRIPYROPENE-C AND PYRIPYROPENE-D

被引：101

作者：

KIM, YK ^{[1
]}

TOMODA, H ^{[1
]}

NISHIDA, H ^{[1
]}

SUNAZUKA, T ^{[1
]}

OBATA, R ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 02期

关键词：

D O I：

10.7164/antibiotics.47.154

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of pyripyropenes A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

引用

页码：154 / 162

页数：9

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