A NEW DOSAGE FORM COMPRISING A SUSPENSION OF ACTIVATED CARBON PARTICLES ADSORBING ACLARUBICIN - TOXICITY IN MICE

被引：3

作者：

HAGIWARA, A ^{[1
]}

TAKAHASHI, T ^{[1
]}

IWAMOTO, A ^{[1
]}

YONEYAMA, C ^{[1
]}

ITO, M ^{[1
]}

SASABE, T ^{[1
]}

MURANISHI, S ^{[1
]}

MATSUMOTO, S ^{[1
]}

机构：

[1] KYOTO COLL PHARM,DEPT BIOPHARMACEUT,YAMASHINA KU,KYOTO 607,JAPAN

来源：

ANTI-CANCER DRUGS | 1991年 / 2卷 / 04期

关键词：

ACLARUBICIN; ACTIVATED CARBON; DRUG DELIVERY SYSTEM; SUBCUTANEOUS ADMINISTRATION; TOXICITY;

D O I：

10.1097/00001813-199108000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new dosage form (ACR-CH), a suspension of small activated carbon particles adsorbing aclarubicin, was studied for its toxicity and histopathological effects on organs in mice. The 50% lethal subcutaneous dose of ACR-CH was 83.5 mg/kg, a value 2.42 times that (34.5 mg/kg) of the aclarubicin aqueous solution. The duration of the toxic effects of ACR-CH was prolonged compared with that of the aclarubicin aqueous solution. On autopsy there was no remarkable difference in macroscopic and microscopic examinations between the two dosage forms.

引用

页码：365 / 369

页数：5

共 6 条

[1]

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TAKAHASHI, T ;

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[3]

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