THE MYTH OF MATERNAL TRANSMISSION OF SPONGIFORM ENCEPHALOPATHY

被引：41

作者：

RIDLEY, RM ^{[1
]}

BAKER, HF ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT EXPTL PSYCHOL, CAMBRIDGE CB2 3EB, ENGLAND

来源：

BRITISH MEDICAL JOURNAL | 1995年 / 311卷 / 7012期

关键词：

D O I：

10.1136/bmj.311.7012.1071

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has long been accepted that the pattern of occurrence of scrapie-the form of spongiform encephalopathy associated with sheep-is determined mainly by maternal transmission, and this view has had a profound influence on policy decisions in the control of bovine spongiform encephalopathy and on public concern over the risk to human health from this disease. The occurrence of maternal transmission is, however, not predicted by modern knowledge of the aetiology of spongiform encephalopathy, and even though claims of maternal transmission have been reiterated frequently in the literature, re-examination of the source data reveals that these data are extremely scanty, unreplicated, and probably subject to ascertainment bias. The probability of maternal transmission of spongiform encephalopathy in any species should be viewed with the greatest scepticism.

引用

页码：1071 / 1075

页数：5

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