CD3G IS WITHIN 200 KB OF THE LEUKEMIC T(4,II) TRANSLOCATION BREAKPOINT

被引：28

作者：

DAS, S ^{[1
]}

COTTER, FE ^{[1
]}

GIBBONS, B ^{[1
]}

DHUT, S ^{[1
]}

YOUNG, BD ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,IMPERIAL CANC RES FUND,MED ONCOL UNIT,LONDON EC1A 7BE,ENGLAND

来源：

GENES CHROMOSOMES & CANCER | 1991年 / 3卷 / 01期

关键词：

D O I：

10.1002/gcc.2870030108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The t(4;11)(q21;q23) has been associated with acute lymphocytic leukemia (ALL) especially in infants. The t(4;11) breakpoint on chromosome 11 is cytogenetically indistinguishable from breakpoints for other leukemia-associated translocations affecting 11q23. The molecular basis of the t(4;11) is unknown although a number of genes have been mapped to 11q23. The CD3D, G, and E genes have been positioned proximal to the 11q23 breakpoint of the 4;11 translocation while the THY1 and EST1 genes have been mapped distal to this breakpoint. We report evidence that CD3G is within 200 kb of the 4;11 breakpoint as observed by pulsed field gel analysis. A rearrangement of the CD3G gene has been observed in a cell line derived from a patient with the t(4;11) translocation and in a hybrid cell line containing the derivative 11q chromosome derived from this cell line, using the restriction enzymes Sac11 and Cla1. Similar rearrangements using Sac11 were observed in 2 further patients with ALL and the t(4;11) translocation. No rearrangements in the same DNA were observed using ETS1, THY1, and D11S29 and a range of rare cutter restriction enzymes. CD3G thus provides a tool for the cloning and analysis of the 4;11 translocation, and poses a question of its possible involvement at long range with this translocation.

引用

页码：44 / 47

页数：4

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