CONFORMATIONAL-ANALYSIS OF 2 ANTI-HIV NUCLEOSIDE ANALOGS 2',3'-DIDEOXY-3'-FLUOROCYTIDINE AND ITS N4-DIMETHYLAMINOMETHYLENE PRODRUG DERIVATIVE

被引：6

作者：

CODY, V ^{[1
]}

KALMAN, TI ^{[1
]}

机构：

[1] SUNY BUFFALO,SCH PHARM,DEPT MED CHEM,BUFFALO,NY 14260

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 2-4期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319208021737

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Crystal structure analysis of 2',3'-dideoxy-3'-fluorocytidine (1) and its prodrug derivative, N4-dimethylaminomethylene-2',3'-dideoxy-3'-fluorocytidine 2), active anti-HIV nucleoside analogues, reveals that both structures adopt an anti conformation about the glycosyl bond. The furanose ring is C2'-endo for (2) and C2'-endo/C1'-exo and C2'-endo/C3'-exo for the two independent molecules of (1), respectively.

引用

页码：731 / 738

页数：8

共 15 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2]

UNUSUAL STRUCTURAL FEATURES OF 2',3'-DIDEOXYCYTIDINE, AN INHIBITOR OF THE HIV (AIDS) VIRUS [J].