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GLYCOSYLATED COLLAGEN

被引：127
作者：
ROSENBERG, H
MODRAK, JB
HASSING, JM
ALTURK, WA
STOHS, SJ
机构：
[1] Department of Biomedicinal Chemistry College, Pharmacy University, Nebraska Medical Center Omaha
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 02期
关键词：
D O I：
10.1016/0006-291X(79)91549-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Collagen was separated from segments of thoracic aorta excised from normal and streptozotocin-induced diabetic rats. The extent of collagen glycosylation was determined using a colorimetric chemical procedure specific for the detection of ketoamine-linked hexoses in proteins. Diabetic rats exhibited a significant increase in glycosylated collagen as compared to normal animals. Glycosylated collagen may contribute to the development of diabetic vascular complications. © 1979.
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页码：498 / 501
页数：4
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