GLYCOSYLATED COLLAGEN

被引：127

作者：

ROSENBERG, H

MODRAK, JB

HASSING, JM

ALTURK, WA

STOHS, SJ

机构：

[1] Department of Biomedicinal Chemistry College, Pharmacy University, Nebraska Medical Center Omaha

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91549-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Collagen was separated from segments of thoracic aorta excised from normal and streptozotocin-induced diabetic rats. The extent of collagen glycosylation was determined using a colorimetric chemical procedure specific for the detection of ketoamine-linked hexoses in proteins. Diabetic rats exhibited a significant increase in glycosylated collagen as compared to normal animals. Glycosylated collagen may contribute to the development of diabetic vascular complications. © 1979.

引用

页码：498 / 501

页数：4

共 14 条

[11] AGE-RELATED CHANGES IN COLLAGEN - IDENTIFICATION OF REDUCIBLE LYSINE-CARBOHYDRATE CONDENSATION PRODUCTS [J].