SINOAORTIC DENERVATION DOES NOT INCREASE CARDIOVASCULAR ENDOCRINE RESPONSES TO STRESS

被引:15
作者
CALLAHAN, MF [1 ]
DAROCHA, MJA [1 ]
MORRIS, M [1 ]
机构
[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,NEUROSCI PROGRAM,WINSTON SALEM,NC 27103
关键词
OXYTOCIN; VASOPRESSIN; HEART RATE; TACHYCARDIA; MEAN ARTERIAL PRESSURE; BARORECEPTOR DENERVATION; SINOAORTIC DENERVATION; HYPERTENSION; RATS;
D O I
10.1159/000126301
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sinoaortic baroreceptor denervation is reported to produce exaggerated centrally derived cardiovascular and endocrine responses. We examined the effect of sinoaortic denervation (SAD) on the cardiovascular and endocrine responses to two acute stressors, footshock and immobilization, in male Sprague-Dawley rats. Parameters measured were mean arterial pressure (MAP), heart rate (HR) and plasma levels of oxytocin (OT) and vasopressin (VP). Baseline MAP was elevated in the SAD group (almost-equal-to 25 mm Hg) and footshock stress increased arterial pressure equivalently in both groups. This stress caused tachycardia and increased plasma OT, with a tendency for the SAD group to show blunted responses. Immobilization increased HR but caused no change in MAP and no significant difference between the groups. This form of stress also increased plasma OT, and again the SAD group showed a diminished response. Plasma VP was not significantly altered by either stressor. The results of these studies indicate that SAD does not uniformly increase the cardiovascular and endocrine responses to all stressors or centrally derived stimuli. These results also suggest that the lack of an increase in plasma VP is not related to baroreceptor-mediated inhibition of secretion under stressful conditions.
引用
收藏
页码:735 / 741
页数:7
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