TOTAL SYNTHESIS OF (+)-DECARESTRICTINE-L

被引：29

作者：

MACHINAGA, N ^{[1
]}

KIBAYASHI, C ^{[1
]}

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)73848-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (+)-decarestrictine L, a member of a new family of inhibitors of cholesterol biosynthesis, has been achieved utilizing a C2 symmetrical diepoxide chiral synthon. The approach involves the construction of the tetrahydropyranyl nucleus by fully stereocontrolled intramolecular 1,4-conjugate addition.

引用

页码：5739 / 5742

页数：4

共 11 条

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