SECONDARY METABOLITES BY CHEMICAL-SCREENING .8. DECARESTRICTINES, A NEW FAMILY OF INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS FROM PENICILLIUM .1. STRAIN DESCRIPTION, FERMENTATION, ISOLATION AND PROPERTIES

被引:128
作者
GRABLEY, S
GRANZER, E
HUTTER, K
LUDWIG, D
MAYER, M
THIERICKE, R
TILL, G
WINK, J
PHILIPS, S
ZEECK, A
机构
[1] HOECHST AG,POSTFACH 800320,W-6230 FRANKFURT 80,GERMANY
[2] UNIV GOTTINGEN,INST ORGAN CHEM,W-3400 GOTTINGEN,GERMANY
关键词
D O I
10.7164/antibiotics.45.56
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A family of new 10-membered lactones was detected by chemical screening. Taxonomic studies and fermentation conditions of the producing organisms, which belong to the species Penicillium simplicissimum and Penicillium corylophilum, are presented. The isolation as well as physico-chemical data of the new compounds named decarestrictines A to D are reported. In vitro testing using the HEP-G2 cell assay showed the decarestrictines to be inhibitors of cholesterol biosynthesis, which could be confirmed in vivo. In addition to the decarestrictines from P. corylophilum epoxyagroclavine-I (1) was isolated.
引用
收藏
页码:56 / 65
页数:10
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