SECONDARY METABOLITES BY CHEMICAL-SCREENING .7.1. ELAIOPHYLIN DERIVATIVES AND THEIR BIOLOGICAL-ACTIVITIES

被引：30

作者：

HAMMANN, P

KRETZSCHMAR, G

SEIBERT, G

机构：

[1] Hoechst Aktiengesellschaft, D-6230 Frankfurt/M.

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 11期

关键词：

D O I：

10.7164/antibiotics.43.1431

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis and the biological activity of 34 acyl derivatives of elaiophylin (1) and 6 deglycosidation products were described. Especially the unsymmetric deglycosidation products 33, 38 and 40 and dimethloctahydroelaiophylin (21) exhibited an activity against nematodes.

引用

收藏

页码：1431 / 1440

页数：10

相关论文

共 26 条

[1]

ARAI M, 1960, J ANTIBIOT, V13, P46

[2]

ARAI M, 1960, J ANTIBIOT, V13, P51

[3]

ARCAMONE F. M., 1959, GIORN MICROBIOL, V7, P207

[4] AVERMECTINS AND MILBEMYCINS [J].

DAVIES, HG ;

GREEN, RH .

NATURAL PRODUCT REPORTS, 1986, 3 (02) :87-121

[5] METABOLIC PRODUCTS OF MICROORGANISMS .200. ISOLATION AND CHARACTERIZATION OF NIPHITHRICIN-A, NIPHITHRICIN-B, AND ELAIOPHYLIN, ANTIBIOTICS PRODUCED BY STREPTOMYCES-VIOLACEONIGER [J].

FIEDLER, HP ;

WORNER, W ;

ZAHNER, H ;

KAISER, HP ;

KELLERSCHIERLEIN, W ;

MULLER, A .

JOURNAL OF ANTIBIOTICS, 1981, 34 (09) :1107-1118

[6] L-155,175 - A NEW ANTIPARASITIC MACROLIDE FERMENTATION, ISOLATION AND STRUCTURE [J].

GOETZ, MA ;

MCCORMICK, PA ;

MONAGHAN, RL ;

OSTLIND, DA ;

HENSENS, OD ;

LIESCH, JM ;

ALBERSSCHONBERG, G .

JOURNAL OF ANTIBIOTICS, 1985, 38 (02) :161-168

[7] SECONDARY METABOLITES BY CHEMICAL-SCREENING .2. AMYCIN-A AND AMYCIN-B, 2, NOVEL NIPHIMYCIN ANALOGS ISOLATED FROM A HIGH PRODUCER STRAIN OF ELAIOPHYLIN AND NIGERICIN [J].

GRABLEY, S ;

HAMMANN, P ;

RAETHER, W ;

WINK, J ;

ZEECK, A .

JOURNAL OF ANTIBIOTICS, 1990, 43 (06) :639-647

[8] SECONDARY METABOLITES BY CHEMICAL-SCREENING .5. CYCLOADDITION REACTIONS OF ELAIOPHYLIN [J].

HAMMANN, P ;

KRETZSCHMAR, G .

TETRAHEDRON, 1990, 46 (16) :5603-5608

[9] SECONDARY METABOLITES BY CHEMICAL-SCREENING .6. CLEAVAGE OF ELAIOPHYLIN AND TRANSFORMATION INTO A SPIROKETAL BUILDING BLOCK [J].

HAMMANN, P ;

KRETZSCHMAR, G .

TETRAHEDRON, 1990, 46 (16) :5609-5616

[10]

HAMMANN P, 1990, Z NATURFORSCH B, V45, P517