RELEASE OF DOPAMINE IS REDUCED BY DIAZEPAM MORE IN THE NUCLEUS-ACCUMBENS THAN IN THE CAUDATE-NUCLEUS OF CONSCIOUS RATS

被引:55
作者
INVERNIZZI, R [1 ]
POZZI, L [1 ]
SAMANIN, R [1 ]
机构
[1] MARIO NEGRI INST PHARMACOL RES, VIA ERITREA 62, I-20157 MILAN, ITALY
关键词
DIAZEPAM; DOPAMINE RELEASE; DOPAMINE METABOLISM; NUCLEUS ACCUMBENS; STRIATUM;
D O I
10.1016/0028-3908(91)90075-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of 1-20 mg/kg diazepam were studied on the extracellular concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the nucleus accumbens and striatum of conscious rats, using intracerebral microdialysis. Five, but not 1 mg/kg diazepam significantly reduced extracellular DA, DOPAC and HVA in the nucleus accumbens. Twenty mg/kg diazepam significantly reduced extracellular DA, DOPAC and HVA in the striatum. A significant effect on striatal DOPAC, but not on DA and HVA, was seen with 10 mg/kg diazepam, while no changes were found with 5 mg/kg diazepam. The results suggest that diazepam reduces the release and metabolism of DA in the nucleus accumbens more than in the striatum.
引用
收藏
页码:575 / 578
页数:4
相关论文
共 35 条
[21]   FACILITATION OF STRIATAL POTASSIUM-INDUCED DOPAMINE RELEASE - NOVEL STRUCTURAL REQUIREMENTS FOR A PRESYNAPTIC ACTION OF BENZODIAZEPINES [J].
MITCHELL, PR ;
MARTIN, IL .
NEUROPHARMACOLOGY, 1980, 19 (01) :147-150
[22]  
Paxinos G., 2007, RAT BRAIN STEROTAXIC
[23]   POSSIBLE GABA-MEDIATED CONTROL OF DOPAMINE-DEPENDENT BEHAVIORAL-EFFECTS FROM NUCLEUS ACCUMBENS OF RAT [J].
PYCOCK, CJ ;
HORTON, RW .
PSYCHOPHARMACOLOGY, 1976, 49 (02) :173-178
[24]   DOPAMINE-DEPENDENT HYPERACTIVITY IN THE RAT FOLLOWING MANIPULATION OF GABA MECHANISMS IN THE REGION OF THE NUCLEUS ACCUMBENS [J].
PYCOCK, CJ ;
HORTON, RW .
JOURNAL OF NEURAL TRANSMISSION, 1979, 45 (01) :17-33
[25]  
SCATTON B, 1988, ANN NY ACAD SCI, V537, P124
[26]   GABA IN THE ENTOPEDUNCULAR NUCLEUS AND THE SUBTHALAMIC NUCLEUS PARTICIPATES IN MEDIATING DOPAMINERGIC STRIATAL OUTPUT FUNCTIONS [J].
SCHEELKRUGER, J ;
MAGELUND, G .
LIFE SCIENCES, 1981, 29 (15) :1555-1562
[27]  
SEPINWALL J, 1980, FED PROC, V39, P3024
[28]   ON THE SACRED DISEASE - THE NEUROCHEMISTRY OF EPILEPSY [J].
SNEAD, OC .
INTERNATIONAL REVIEW OF NEUROBIOLOGY, 1983, 24 :93-180
[29]   DIAZEPAM-INDUCED PLACE PREFERENCE CONDITIONING - APPETITIVE AND ANTIAVERSIVE PROPERTIES [J].
SPYRAKI, C ;
KAZANDJIAN, A ;
VARONOS, D .
PSYCHOPHARMACOLOGY, 1985, 87 (02) :225-232
[30]   GABA MODULATES THE RELEASE OF DOPAMINE AND ACETYLCHOLINE FROM RAT CAUDATE-NUCLEUS SLICES [J].
STOOF, JC ;
DENBREEJEN, EJS ;
MULDER, AH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 57 (01) :35-42