EFFECT OF OCTREOTIDE ON SPHINCTER OF ODDI AND GALLBLADDER MOTILITY IN PRAIRIE DOGS

被引:19
作者
AHRENDT, SA [1 ]
AHRENDT, GM [1 ]
LILLEMOE, KD [1 ]
PITT, HA [1 ]
机构
[1] BALTIMORE VET AFFAIRS MED CTR,SURG SERV,BALTIMORE,MD 21205
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 05期
关键词
CHOLECYSTOKININ; CHOLINERGIC NERVES; GALLSTONES; GASTROINTESTINAL MOTILITY; INNERVATION; SOMATOSTATIN;
D O I
10.1152/ajpgi.1992.262.5.G909
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Somatostatin and its synthetic analogue, octreotide, inhibit gallbladder emptying and cause gallstones. Whether octreotide-induced alterations in sphincter of Oddi motility contribute to this process is unknown. We, therefore, examined the effect of octreotide on fasting and protein-stimulated sphincter of Oddi motility. In 25 anesthetized prairie dogs, sphincter of Oddi motility and gallbladder pressure were monitored during the intravenous administration of octreotide, cholecystokinin (CCK) octapeptide, atropine, the intraduodenal administration of casein, and combinations of these agents. Intravenous octreotide decreased fasting sphincter of Oddi motility index both with (59 +/- 19 vs. 84 +/- 28, P < 0.05) and without (137 +/- 31 vs. 227 +/- 42, P < 0.05) prior cholinergic blockade with atropine. Octreotide also prevented the increases in sphincter of Oddi motility and gallbladder pressure seen with intraduodenal casein. Exogenous CCK increased sphincter of Oddi motility index and gallbladder pressure despite the simultaneous administration of octreotide alone (357 +/- 109 vs. 137 +/- 31, P < 0.07, and 11.2 +/- 1.0 mmHg vs. 9.6 +/- 0.6 mmHg, P < 0.05) or the combination of octreotide and atropine (317 +/- 69 vs. 59 +/- 19, P < 0.05, and 10.1 +/- 1.6 mmHg vs. 8.5 +/- 1.4 mmHg, P < 0.05). We conclude that both a cholinergic and an octreotide-sensitive noncholinergic pathway stimulate fasting sphincter of Oddi motility in the prairie dog.
引用
收藏
页码:G909 / G914
页数:6
相关论文
共 34 条
  • [11] INTRAMURAL NEURAL CONTROL OF OPOSSUM SPHINCTER OF ODDI
    HELM, JF
    DODDS, WJ
    CHRISTENSEN, J
    SARNA, SK
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06): : G925 - G929
  • [12] RELATIONSHIP OF SPHINCTER OF ODDI SPIKE BURSTS TO GASTROINTESTINAL MYOELECTRIC ACTIVITY IN CONSCIOUS OPOSSUMS
    HONDA, R
    TOOULI, J
    DODDS, WJ
    SARNA, S
    HOGAN, WJ
    ITOH, Z
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (04) : 770 - 778
  • [13] PANCREATIC EXOCRINE AND GALLBLADDER FUNCTION DURING LONG-TERM TREATMENT WITH OCTREOTIDE (SMS-201-995)
    HOPMAN, WPM
    VANLIESSUM, PA
    PIETERS, GFFM
    SMALS, AGH
    TANGERMAN, A
    JANSEN, JBMJ
    ROSENBUSCH, G
    LAMERS, CBHW
    KLOPPENBORG, PWC
    [J]. DIGESTION, 1990, 45 : 72 - 76
  • [14] KEANE FB, 1980, GASTROENTEROLOGY, V78, P310
  • [15] SOMATOSTATIN MODULATES CHOLINERGIC NEUROTRANSMISSION IN CANINE ANTRAL MUSCLE
    KOELBEL, CB
    VANDEVENTER, G
    KHAWAJA, S
    MOGARD, M
    WALSH, JH
    MAYER, EA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (02): : G201 - G209
  • [16] EFFECT OF LONG-ACTING SOMATOSTATIN-ANALOGUE, SMS 201995, ON GUT HORMONE-SECRETION IN NORMAL SUBJECTS
    KRAENZLIN, ME
    WOOD, SM
    NEUFELD, M
    ADRIAN, TE
    BLOOM, SR
    [J]. EXPERIENTIA, 1985, 41 (06): : 738 - 740
  • [17] LEMBCKE B, 1987, DIGESTION, V36, P100
  • [18] PROTEINS BUT NOT AMINO-ACIDS, CARBOHYDRATES, OR FATS STIMULATE CHOLECYSTOKININ SECRETION IN THE RAT
    LIDDLE, RA
    GREEN, GM
    CONRAD, CK
    WILLIAMS, JA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (02): : G243 - G248
  • [19] LIN TM, 1977, FED PROC, V36, P557
  • [20] MATON P, 1989, ANN INTERN MED, V110, P35