SYNTHESIS AND BIOLOGICAL-ACTIVITY OF BENZOTRIAZOLE DERIVATIVES STRUCTURALLY RELATED TO TRAZODONE

被引：38

作者：

CALIENDO, G

DICARLO, R

GRECO, G

MELI, R

NOVELLINO, E

PERISSUTTI, E

SANTAGADA, V

机构：

[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM FARMACEUT & TOSSICOL,I-80131 NAPLES,ITALY

[2] UNIV NAPLES FEDERICO II,DIPARTIMENTO FARMACOL SPERIMENTALE,I-80131 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 01期

关键词：

BENZOTRIAZOLE; ANTISEROTONERGIC ACTIVITY; ANTIADRENERGIC ACTIVITY; ANTIHISTAMINIC ACTIVITY; ANALGESIC ACTIVITY;

D O I：

10.1016/0223-5234(96)88212-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.

引用

页码：77 / 84

页数：8

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