PREPARATIVE SEPARATION AND ANALYSIS OF THE ENANTIOMERS OF [C-14] ZILEUTON, A 5-LIPOXYGENASE INHIBITOR

被引：10

作者：

THOMAS, SB ^{[1
]}

SURBER, BW ^{[1
]}

FITZGERALD, M ^{[1
]}

机构：

[1] ABBOTT LABS,CAPD PROC RES,N CHICAGO,IL 60064

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 623卷 / 02期

关键词：

D O I：

10.1016/0021-9673(92)80382-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Preparative resolution and quantitative methodology for the optical purity determination of [C-14]Zileuton, N-[1-C-14]1-(benzo[b]thien-2-yl)ethyl-N-hydroxyurea, [C-14]Abbott-64077, a 5-lipoxygenase inhibitor with potential clinical applications in the treatment of inflammatory diseases, is described. The method involves the use of a chiral stationary phase composed of amylose tris(3,5-dimethylphenylcarbamate) chemically bonded to 3-aminopropyl silica gel (ChiralPak AD) and a mobile phase consisting of n-hexane-ethanol (90:10). Optical and radiochemical purities of > 99% were achieved for both.

引用

页码：390 / 394

页数：5

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