MONITORING SKELETAL CANCER METASTASES WITH THE BONE ISOENZYME OF TISSUE UNSPECIFIC ALKALINE-PHOSPHATASE

被引：18

作者：

BURLINA, A

RUBIN, D

SECCHIERO, S

SCIACOVELLI, L

ZANINOTTO, M

PLEBANI, M

机构：

[1] UNIV HOSP PADOVA, CTR BIOMED RES, I-35128 PADUA, ITALY

[2] UNIV HOSP PADOVA, DEPT LAB MED, I-35128 PADUA, ITALY

来源：

CLINICA CHIMICA ACTA | 1994年 / 226卷 / 02期

关键词：

SKELETAL METASTASES; ALKALINE PHOSPHATASE; BONE FRACTION; WHEAT-GERM LECTIN;

D O I：

10.1016/0009-8981(94)90212-7

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The efficacy of bone alkaline phosphatase (ALP) isoenzyme measurement using lectin precipitation in confirming metastatic bone lesions was compared with total ALP and osteocalcin assay in serum. Sixty-five patients with cancer and metastases to bone (n = 44), liver (n = 15) or lymph nodes (n = 6) as well as 33 healthy adutls were studied. Assay of bone ALP is as sensitive but more specific than assay of total ALP in the identification of bone metastases. On the other hand, bone ALP did not correlate with osteocalcin, as is the case in other bone diseases. In the serial monitoring of nine patients with skeletal metastases, bone ALP correlated well with the presence of pain and the progression or regression of metastatic spread.

引用

页码：151 / 158

页数：8