Modest reduction of benzodiazepine binding in rat brain in vivo induced by antisense oligonucleotide to GABA(A) receptor gamma(2) subunit subtype

被引：12

作者：

Karle, J

Nielsen, M

机构：

[1] The Research Institute of Biological Psychiatry, St. Hans Psychiatric Hospital

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1995年 / 291卷 / 03期

关键词：

GABA(A) receptor; antisense oligonucleotide; receptor subunit; benzodiazepine receptor; brain; rat;

D O I：

10.1016/0922-4106(95)90088-8

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The GABA(A) (gamma-aminobutyric acid-A) receptor gamma(2) subunit subtype is probably a functionally integral part of the benzodiazepine binding site of the GABA(A) receptor complex, important for benzodiazepine pharmacology. We have evaluated the possibility of specifically reducing benzodiazepine receptor binding properties in vivo using phosphorothioate antisense oligodeoxynucleotides to inhibit the expression of GABA(A) receptor gamma(2) subunit subtype. Intracerebroventricular infusions of an antisense oligonucleotide reduced benzodiazepine receptor radioligand binding by 9-15% in specific rat brain regions.

引用

收藏

页码：439 / 441

页数：3

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