EFFECTS OF INTERLEUKIN-1-ALPHA - ADMINISTRATION ON PITUITARY-ADRENAL AND PITUITARY-THYROID AXES FUNCTION OF PATIENTS WITH OVARIAN-CANCER

被引：3

作者：

VASSILOPOULOUSELLIN, R

KUDELKA, AP

KAVANAGH, JJ

EDWARDS, CL

VADHANRAJ, S

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT CLIN IMMUNOL & BIOL THERAPY, HOUSTON, TX 77030 USA

[2] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT BREAST & GYNECOL MED ONCOL, HOUSTON, TX USA

[3] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT GYNECOL ONCOL, DIV SURG, HOUSTON, TX USA

来源：

JOURNAL OF IMMUNOTHERAPY | 1995年 / 17卷 / 02期

关键词：

PITUITARY GLAND; ADRENAL GLAND; THYROID FUNCTION; INTERLEUKIN; 1-ALPHA; OVARIAN CANCER;

D O I：

10.1097/00002371-199502000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We monitored pituitary, adrenal, and thyroid function in 21 women who had recurrent ovarian cancer and who received interleukin-1 alpha (IL-1 alpha) before and after carboplatin. Serum cortisol, corticotropin, thyroxine, and thyrotropin were measured in the morning before and at the end of each treatment cycle. Serum corticotropin levels were suppressed in many patients despite a normal simultaneous serum cortisol; thyrotropin tended to rise with declining thyroxine levels after prolonged IL-1 alpha administration. However, serum cortisol and thyroxine remained within the normal range at all times, in all patients. Thyroid dysfunction consistent with thyroiditis was seen in one patient. We conclude that administration of IL-1 alpha as currently used in clinical studies does not create significant thyroid or adrenocortical dysfunction.

引用

页码：109 / 113

页数：5