THE CEPH CONSORTIUM LINKAGE MAP OF HUMAN-CHROMOSOME-16

被引：21

作者：

KOZMAN, HM

KEITH, TP

DONISKELLER, H

WHITE, RL

WEISSENBACH, J

DEAN, M

VERGNAUD, G

KIDD, K

GUSELLA, J

ROYLE, NJ

SUTHERLAND, GR

MULLEY, JC

机构：

[1] WOMENS & CHILDRENS HOSP,CTR MED GENET,DEPT CYTOGENET & MOLEC GENET,ADELAIDE,SA 5006,AUSTRALIA

[2] UNIV ADELAIDE,DEPT PAEDIAT,ADELAIDE,SA,AUSTRALIA

[3] COLLABORAT RES INC,DEPT HUMAN & MOLEC GENET,WALTHAM,MA

[4] WASHINGTON UNIV,SCH MED,DEPT SURG,ST LOUIS,MO 63110

[5] UNIV UTAH,HOWARD HUGHES MED INST,SALT LAKE CITY,UT

[6] INST PASTEUR,PARIS,FRANCE

[7] NCI,FREDERICK CANC RES FACIL,FREDERICK,MD

[8] CTR ETUD BOUCHET,NANTES,FRANCE

[9] INST BIOL,NANTES,FRANCE

[10] YALE UNIV,SCH MED,DEPT HUMAN GENET,NEW HAVEN,CT 06510

[11] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114

[12] UNIV LEICESTER,DEPT GENET,LEICESTER LE1 7RH,LEICS,ENGLAND

来源：

GENOMICS | 1995年 / 25卷 / 01期

关键词：

D O I：

10.1016/0888-7543(95)80108-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A Centre d'Etude du Polymorphisme Humain (CEPH) consortium map of human chromosome 16 has been constructed. The map contains 158 loci defined by 191 different probe/restriction enzyme combinations or primer pairs. The marker genotypes, contributed by 9 collaborating laboratories, originated from the CEPH families DNA. A total of 60 loci, with an average heterozygosity of 68%, have been placed on the framework genetic map. The genetic map contains 7 genes. The length of the sex-averaged map is 165 cM, with a mean genetic distance between loci of 2.8 cM; the median distance between markers is 2.0 cM. The male map length is 136 cM, and the female map length is 197 cM. The map covers virtually the entire chromosome, from D16S85, within 170 to 430 kb of the 16p telomere, to D16S303 at 16qter. The markers included in the linkage map have been physically mapped on a partial human chromosome 16 somatic cell hybrid panel, thus anchoring the genetic map to the cytogenetic-based physical map. (C) 1995 Academic Press, Inc.

引用

页码：44 / 58

页数：15

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