PROTECTION OF MICE FROM MYCOBACTERIUM-AVIUM INFECTION BY RECOMBINANT INTERLEUKIN-12

被引：26

作者：

KOBAYASHI, K

KASAMA, T

YAMAZAKI, J

HOSAKA, M

KATSURA, T

MOCHIZUKI, T

SOEJIMA, K

NAKAMURA, RM

机构：

[1] SHOWA UNIV,SCH MED,DEPT PATHOL,SHINAGAWA KU,TOKYO 142,JAPAN

[2] NATL INST HLTH,DEPT BACTERIOL,DIV MYCOBACTERIOL,SHINJUKU KU,TOKYO 162,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 06期

关键词：

D O I：

10.1128/AAC.39.6.1369

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.

引用

页码：1369 / 1371

页数：3

共 22 条

[1] RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ENHANCES THE EFFECTS OF ANTIBIOTICS AGAINST MYCOBACTERIUM-AVIUM COMPLEX INFECTION IN THE BEIGE MOUSE MODEL [J].