PHARMACOLOGICAL AND IMMUNOHISTOCHEMICAL EVIDENCE FOR SEROTONERGIC MODULATION OF CHOLINERGIC NUCLEUS BASALIS NEURONS

被引：94

作者：

KHATEB, A

FORT, P

ALONSO, A

JONES, BE

MUHLETHALER, M

机构：

[1] UNIV GENEVA, MED CTR, DEPT PHYSIOL, 1 RUE MICHEL SERVET, CH-1211 GENEVA 4, SWITZERLAND

[2] MCGILL UNIV, MONTREAL NEUROL INST, DEPT NEUROL & NEUROSURG, MONTREAL H3A 2B4, QUEBEC, CANADA

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1993年 / 5卷 / 05期

关键词：

LOW THRESHOLD SPIKE; 5-HT(1A) RECEPTOR; SUBSTANTIA INNOMINATA; SLEEP; GUINEA-PIG;

D O I：

10.1111/j.1460-9568.1993.tb00519.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea-pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin-immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin-labelled, choline acetyl transferase (ChAT)-immunoreactive cells. By bath application, 5-hydroxytryptamine (5-HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5-HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons.

引用

页码：541 / 547

页数：7

共 54 条

[11] NEURONAL FIRING IN THE PALLIDAL REGION - FIRING PATTERNS DURING SLEEP-WAKEFULNESS CYCLE IN CATS
DETARI, L
JUHASZ, G
KUKORELLI, T
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1987, 67 (02): : 159 - 166
[12] EFFECTS OF INTRACEREBRAL INJECTION OF 5,6-HYDROXYTRYPTAMINE ON CEREBRAL MONOAMINES AND SLEEPING STATES OF CAT
FROMENT, JL
PETITJEAN, F
BERTRAND, N
COINTY, C
JOUVET, M
[J]. BRAIN RESEARCH, 1974, 67 (03) : 405 - 417
[13] CODISTRIBUTION OF GABA-SYNTHESIZING WITH ACETYLCHOLINE-SYNTHESIZING NEURONS IN THE BASAL FOREBRAIN OF THE RAT
GRITTI, I
MAINVILLE, L
JONES, BE
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 329 (04) : 438 - 457
[14] A VERSATILE MEANS OF INTRACELLULAR LABELING - INJECTION OF BIOCYTIN AND ITS DETECTION WITH AVIDIN CONJUGATES
HORIKAWA, K
ARMSTRONG, WE
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1988, 25 (01) : 1 - 11
[15] JACOBS BL, 1991, PHARMACOL REV, V43, P563
[16] AFFERENTS TO THE BASAL FOREBRAIN CHOLINERGIC CELL AREA FROM PONTOMESENCEPHALIC CATECHOLAMINE, SEROTONIN, AND ACETYLCHOLINE NEURONS
JONES, BE
CUELLO, AC
[J]. NEUROSCIENCE, 1989, 31 (01) : 37 - 61
[17] THE EFFERENT PROJECTIONS FROM THE RETICULAR-FORMATION AND THE LOCUS COERULEUS STUDIED BY ANTEROGRADE AND RETROGRADE AXONAL-TRANSPORT IN THE RAT
JONES, BE
YANG, TZ
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 242 (01) : 56 - 92
[18] JOUVET M, 1975, CHOLINERGIC MECHANIS
[19] JOUVET M, 1972, ERGEBN PHYSIOL, V64, P165
[20] CHOLINERGIC NUCLEUS BASALIS NEURONS DISPLAY THE CAPACITY FOR RHYTHMIC BURSTING ACTIVITY MEDIATED BY LOW-THRESHOLD CALCIUM SPIKES
KHATEB, A
MUHLETHALER, M
ALONSO, A
SERAFIN, M
MAINVILLE, L
JONES, BE
[J]. NEUROSCIENCE, 1992, 51 (03) : 489 - 494

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