OCCURRENCE OF AN SN(ANRORC) MECHANISM IN THE CHICHIBABIN AMINATION OF 4-PHENYLPYRIMIDINE .78.

被引：20

作者：

BREUKER, K ^{[1
]}

VANDERPLAS, HC ^{[1
]}

机构：

[1] AGR UNIV,ORGAN CHEM LAB,NL-6703 BC WAGENINGEN,NETHERLANDS

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 25期

关键词：

D O I：

10.1021/jo00393a043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oil treatment of 4-phenylpyrimidine with potassium amide in liquid ammonia, a mixture of 6-amino-4-phenylpyrirnidine and 2-amino-4-phenylpyrimidine is obtained. It was proven that in the formation of the 2-amino compound the pyrimidine ring is opened but that in the formation of the 6-amino compound no ring opening is involved, 1H and 13C NMR spectroscopy gave evidence for formation of two σ adducts between the amide ion and 4-phenylpyrimidine, i.e., the 6-amino-1(or 3),6-dihydropyrimidinide ion and the 2-amino-1(or 3),2-dihydropyrimidinide ion. © 1979, American Chemical Society. All rights reserved.

引用

页码：4677 / 4680

页数：4

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