NEW DEVELOPMENTS IN CARDIOVASCULAR MAGNETIC-RESONANCE-IMAGING AND SPECTROSCOPY

被引：9

作者：

RUDIN, M

ZIERHUT, W

SAUTER, A

COOK, NS

机构：

[1] SANDOZ PHARMA,CNS DEPT,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

[2] SANDOZ PHARMA,DEPT CARDIOVASC,CH-4002 BASEL,SWITZERLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 11期

关键词：

D O I：

10.1016/0165-6147(91)90620-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methodological improvements in nuclear magnetic resonance (NMR) imaging and spectroscopy have enabled the application of these techniques to the study of functional or dynamic biological processes. Because the techniques are non-invasive, repeated measurements can be made in the same animal at different time points, allowing progression and regression to be followed during drug therapy. In this review, Markus Rudin, Wolfgang Zierhut, Andre' Sauter and Nigel Cook illustrate this concept by the use of NMR to evaluate cardiovascular function in the rat in various physiological and pathological situations. The possibility of using NMR to perform similar studies in both animals and humans should lead to the design of preclinical models with an improved clinical predictability.

引用

页码：416 / 421

页数：6

共 25 条

[11] PHOSPHOCREATINE CONTENT AND INTRACELLULAR PH OF CALF MUSCLE MEASURED BY PHOSPHORUS NMR-SPECTROSCOPY IN OCCLUSIVE ARTERIAL-DISEASE OF THE LEGS [J].