9-AMINOACRIDINE INHIBITS THE B-Z TRANSITION OF POLY(DA-DT)

被引:8
作者
GARRIGA, P [1 ]
QUINTANA, DG [1 ]
MANYOSA, J [1 ]
机构
[1] UNIV AUTONOMA BARCELONA, DEPT BIOQUIM & BIOL MOLEC, UNITAT BIOFIS, EDIFICI M, E-08193 BARCELONA, SPAIN
关键词
D O I
10.1016/S0006-291X(05)80962-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
9-Aminoacridine is the parent compound of a family of pharmacologically active model substances that bind to DNA through intercalation between base pairs. In the present study we show that 9-aminoacridine inhibits the B-to-Z isomerization of poly(dA-dT) in conditions that otherwise cause it to occur (5 M NaCl and 123 mM Ni(ClO4)2). Higher concentrations of Ni(ClO4)2 (155 mM) are able to induce the Z-form due to the disruption of the drug-polynucleotide interaction by the metal ion. Additionally, the dye reverses the Z-form in certain conditions. Thus, the data from this study indicate that 9-aminoacridine binds preferentially to the B-form of poly(dA-dT). © 1992 Academic Press, Inc.
引用
收藏
页码:110 / 115
页数:6
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