NEW IMMUNOSUPPRESSIVE DRUGS - NEEDS IN AND APPLICATIONS TO PEDIATRIC TRANSPLANTATION

被引：5

作者：

KAHAN, BD

机构：

[1] Division of Immunology and Organ Transplant, Department of Surgery, The University of Texas Medical School at Houston, Houston, 77030, TX, 6431 Fannin

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1992年 / 151卷

关键词：

IMMUNOSUPPRESSION; DRUG INTERACTIONS; CYCLOSPORINE;

D O I：

10.1007/BF02125796

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The evolution of immunosuppressive therapy toward synergistic drug combinations seeks to minimize toxicity while potentiating efficacy. Median effect analysis discerns synergistic drug combinations that may be suitable for in vivo experiments in animals and for subsequent clinical trials. These studies suggest that two drugs rapamycin (RAPA) and brequinar (BQR) display synergistic effects in combination with cyclosporine. This combination must be evaluated for relative toxicity versus efficacy. Clinical trials to assess the individual toxicities of RAPA and BQR are presently underway in order to discern appropriate doses for randomized trials of clinical efficacy.

引用

页码：S9 / S12

页数：4

共 32 条

[1] A RANDOMIZED TRIAL COMPARING DOUBLE-DRUG AND TRIPLE-DRUG THERAPY IN PRIMARY CADAVERIC RENAL-TRANSPLANTS [J].

BRINKER, KR ;

DICKERMAN, RM ;

GONWA, TA ;

HULL, AR ;

LANGLEY, JW ;

LONG, DL ;

NESSER, DA ;

TREVINO, G ;

VELEZ, RL ;

VERGNEMARINI, PJ .

TRANSPLANTATION, 1990, 50 (01) :43-49

[2] QUANTITATIVE-ANALYSIS OF DOSE-EFFECT RELATIONSHIPS - THE COMBINED EFFECTS OF MULTIPLE-DRUGS OR ENZYME-INHIBITORS [J].

CHOU, TC ;

TALALAY, P .

ADVANCES IN ENZYME REGULATION, 1984, 22 :27-55

[3]

CRAMER DV, 1992, IN PRESS TRANSPLANTA

[4]

DIDLAKE RH, 1988, TRANSPLANTATION, V45, P353

[5] THE IMMUNE STATUS OF UREMIC CHILDREN ADOLESCENTS WITH CHRONIC RENAL-FAILURE AND RENAL REPLACEMENT THERAPY [J].

DRACHMAN, R ;

SCHLESINGER, M ;

SHAPIRA, H ;

DRUKKER, A .

PEDIATRIC NEPHROLOGY, 1989, 3 (03) :305-308

[6] REGULATION OF ALLOREACTIVITY INVIVO BY A SOLUBLE FORM OF THE INTERLEUKIN-1 RECEPTOR [J].

FANSLOW, WC ;

SIMS, JE ;

SASSENFELD, H ;

MORRISSEY, PJ ;

GILLIS, S ;

DOWER, SK ;

WIDMER, MB .

SCIENCE, 1990, 248 (4956) :739-742

[7]

FANSLOW WC, 1991, J IMMUNOL, V147, P535

[8] CYCLOPHILIN AND PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ARE PROBABLY IDENTICAL PROTEINS [J].

FISCHER, G ;

WITTMANNLIEBOLD, B ;

LANG, K ;

KIEFHABER, T ;

SCHMID, FX .

NATURE, 1989, 337 (6206) :476-478

[9] SUPPRESSOR T-CELLS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE [J].

HALL, BM ;

JELBART, ME ;

DORSCH, SE .

TRANSPLANTATION, 1984, 37 (06) :595-600

[10] CYCLOPHILIN - A SPECIFIC CYTOSOLIC BINDING-PROTEIN FOR CYCLOSPORIN-A [J].

HANDSCHUMACHER, RE ;

HARDING, MW ;

RICE, J ;

DRUGGE, RJ .

SCIENCE, 1984, 226 (4674) :544-547

← 1 2 3 4 →