FORMATION OF GALACTOSE-1-PHOSPHATE FROM URIDINE DIPHOSPHATE GALACTOSE IN ERYTHROCYTES FROM PATIENTS WITH GALACTOSEMIA

被引：42

作者：

GITZELMANN, R

机构：

[1] Laboratory for Metabolic Research, University Pediatric Department, Kinderspital Zurich

[2] Laboratory for Metabolic Research, University Pediatric Department, Zurich, 8032

来源：

PEDIATRIC RESEARCH | 1969年 / 3卷 / 04期

关键词：

Erythrocytes; Galactose; Galactose-1-phosphate; Galactosemia; Uridine diphosphate galactose;

D O I：

10.1203/00006450-196907000-00003

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Extract: Erythrocyte lysates of galactosemic patients were found to form galactose-1-phosphate from uridine diphosphate galactose. The enzymatic reaction most likely responsible for this conversion is uridine diphosphate galactose pyrophosphorylase, an enzyme believed to be absent from human erythrocytes, but other reactions might be involved. Speculation: Galactose-1-phosphate concentration in red cells of galactosemic infants may prove useless as an indicator of galactose uptake from foodstuffs. © International Pediatrics Research Foundation, Inc. 1969. All Rights Reserved.

引用

页码：279 / +

页数：1