A COMPARISON OF THE EFFECTS OF PROPOFOL WITH OTHER ANESTHETIC AGENTS ON THE CENTRIPETAL TRANSMISSION OF SENSORY INFORMATION

被引：37

作者：

ANGEL, A

LEBEAU, F

机构：

[1] Department of Biomedical Science, The University, Sheffield

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 06期

关键词：

D O I：

10.1016/0306-3623(92)90273-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. A range of anaesthetic agents affect the centripetal transmission of sensor 2. This transmission of information through thalamic sensory relay nuclei is impeded and the sensory flow to the cerebral cortex is considerably reduced. 3. In addition cortical transfer of information is blocked since cells in layers III and V show an additional sensitivity to anaesthetic agents. 4. Diprivan (2,6-diisopropylphenol, propofol, ICI) appears to exert an action on sensory transmission mainly by acting on cortical cells in layers III and V. 5. Its action on thalamic sensory relay cells is to increase their latency of discharge and disrupt their pattern of firing.

引用

页码：945 / 963

页数：19

共 38 条

[1] Impulses in the pyramidal tract
Adrian, ED
Moruzzi, G
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1939, 97 (02): : 153 - 199
[2] AMASSIAN VE, 1955, C INT CENT NATN RECH, V65, P353
[3] EFFECT OF ANESTHETIC AGENTS ON PRIMARY CORTICAL EVOKED-RESPONSES
ANGEL, A
BERRIDGE, DA
UNWIN, J
[J]. BRITISH JOURNAL OF ANAESTHESIA, 1973, 45 (08) : 824 - 836
[4] ANGEL A, 1991, EXP PHYSIOL, V76, P1
[5] PRESSURE REVERSAL OF THE EFFECT OF URETHANE ON THE EVOKED SOMATOSENSORY CORTICAL RESPONSE IN THE RAT
ANGEL, A
GRATTON, DA
HALSEY, MJ
WARDLEYSMITH, B
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1980, 70 (02) : 241 - 247
[6] THE EFFECT OF ANESTHETIC AGENTS ON CEREBRAL CORTICAL RESPONSES IN THE RAT
ANGEL, A
GRATTON, DA
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1982, 76 (04) : 541 - 549
[7] CENTRAL CONTROL OF SENSORY TRANSMISSION AND ITS POSSIBLE RELATION TO REACTION TIME
ANGEL, A
[J]. ACTA PSYCHOLOGICA, 1969, 30 : 339 - &
[8] ANGEL A, 1986, J PHYSIOL-LONDON, V378, pP44
[9] ANGEL A, 1983, J PHYSIOL-LONDON, V345, pP17
[10] ANGEL A, 1970, J PHYSIOL-LONDON, V208, pP32

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