A COMPARISON OF THE EFFECTS OF PROPOFOL WITH OTHER ANESTHETIC AGENTS ON THE CENTRIPETAL TRANSMISSION OF SENSORY INFORMATION

被引：37

作者：

ANGEL, A

LEBEAU, F

机构：

[1] Department of Biomedical Science, The University, Sheffield

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 06期

关键词：

D O I：

10.1016/0306-3623(92)90273-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. A range of anaesthetic agents affect the centripetal transmission of sensor 2. This transmission of information through thalamic sensory relay nuclei is impeded and the sensory flow to the cerebral cortex is considerably reduced. 3. In addition cortical transfer of information is blocked since cells in layers III and V show an additional sensitivity to anaesthetic agents. 4. Diprivan (2,6-diisopropylphenol, propofol, ICI) appears to exert an action on sensory transmission mainly by acting on cortical cells in layers III and V. 5. Its action on thalamic sensory relay cells is to increase their latency of discharge and disrupt their pattern of firing.

引用

页码：945 / 963

页数：19

共 38 条

[11] ANGEL A, 1983, SOMATOSENSORY INTEGR, P221
[12] ANGEL A, 1984, NEUROBIOLOGY PAIN, P359
[13] BANNA NR, 1969, INT J NEUROPHARMACOL, V9, P533
[14] EFFECTS OF THE ANESTHETIC 2,6-DIISOPROPYLPHENOL ON SYNAPTIC TRANSMISSION IN THE RAT OLFACTORY CORTEX SLICE
COLLINS, GGS
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (03) : 939 - 949
[15] DAWSON GD, 1963, J PHYSL, V163, P363
[16] DEWILDT DJ, 1983, BRIT J PHARMACOL, V79, P461
[17] PHARMACOLOGICAL STUDIES ON PRESYNAPTIC INHIBITION
ECCLES, JC
WILLIS, WD
SCHMIDT, R
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1963, 168 (03): : 500 - +
[18] EGER EI, 1969, ANESTHESIOLOGY, V30, P129
[19] PRESSURE REVERSAL OF NARCOSIS PRODUCED BY ANESTHETICS, NARCOTICS AND TRANQUILIZERS
HALSEY, MJ
WARDLEYSMITH, B
[J]. NATURE, 1975, 257 (5529) : 811 - 813
[20] EFFECT OF ISOFLURANE ON THE AUDITORY EVOKED-RESPONSE IN MAN
HENEGHAN, CPH
THORNTON, C
NAVARATNARAJAH, M
JONES, JG
[J]. BRITISH JOURNAL OF ANAESTHESIA, 1987, 59 (03) : 277 - 282

← 1 2 3 4 →