ROLE OF THE BETA-AMYLOID PRECURSOR PROTEIN IN ALZHEIMERS-DISEASE

被引：100

作者：

ASHALL, F

GOATE, AM

机构：

[1] F. Ashall and A.M. Goate are, the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1016/0968-0004(94)90173-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease - a prerequisite for rational drug development.

引用

页码：42 / 46

页数：5

共 35 条

[1] Alzheimer A., 1907, ALLG Z PSYCHIATR PS, V64, P146, DOI DOI 10.1002/CA.980080612
[2] DIFFERENTIAL BRAIN EXPRESSION OF THE ALZHEIMERS AMYLOID PRECURSOR PROTEIN
ANDERSON, JP
REFOLO, LM
WALLACE, W
MEHTA, P
KRISHNAMURTHI, M
GOTLIB, J
BIERER, L
HAROUTUNIAN, V
PERL, D
ROBAKIS, NK
[J]. EMBO JOURNAL, 1989, 8 (12) : 3627 - 3632
[3] ANDERSON JP, 1992, J NEUROCHEM, V59, P2328
[4] PROCESSING OF ALZHEIMER BETA-A4 AMYLOID PRECURSOR PROTEIN - MODULATION BY AGENTS THAT REGULATE PROTEIN-PHOSPHORYLATION
BUXBAUM, JD
GANDY, SE
CICCHETTI, P
EHRLICH, ME
CZERNIK, AJ
FRACASSO, RP
RAMABHADRAN, TV
UNTERBECK, AJ
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) : 6003 - 6006
[5] CHOLINERGIC AGONISTS AND INTERLEUKIN-1 REGULATE PROCESSING AND SECRETION OF THE ALZHEIMER BETA/A4 AMYLOID PROTEIN-PRECURSOR
BUXBAUM, JD
OISHI, M
CHEN, HI
PINKASKRAMARSKI, R
JAFFE, EA
GANDY, SE
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10075 - 10078
[6] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR
CAI, XD
GOLDE, TE
YOUNKIN, SG
[J]. SCIENCE, 1993, 259 (5094) : 514 - 516
[7] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION
CITRON, M
OLTERSDORF, T
HAASS, C
MCCONLOGUE, L
HUNG, AY
SEUBERT, P
VIGOPELFREY, C
LIEBERBURG, I
SELKOE, DJ
[J]. NATURE, 1992, 360 (6405) : 672 - 674
[8] CLEAVAGE OF AMYLOID-BETA PEPTIDE DURING CONSTITUTIVE PROCESSING OF ITS PRECURSOR
ESCH, FS
KEIM, PS
BEATTIE, EC
BLACHER, RW
CULWELL, AR
OLTERSDORF, T
MCCLURE, D
WARD, PJ
[J]. SCIENCE, 1990, 248 (4959) : 1122 - 1124
[9] POTENTIALLY AMYLOIDOGENIC, CARBOXYL-TERMINAL DERIVATIVES OF THE AMYLOID PROTEIN-PRECURSOR
ESTUS, S
GOLDE, TE
KUNISHITA, T
BLADES, D
LOWERY, D
EISEN, M
USIAK, M
QU, XM
TABIRA, T
GREENBERG, BD
YOUNKIN, SG
[J]. SCIENCE, 1992, 255 (5045) : 726 - 728
[10] CHARACTERIZATION OF 2 PATHOLOGICAL TAU-PROTEIN VARIANTS IN ALZHEIMER BRAIN CORTICES
FLAMENT, S
DELACOURTE, A
HEMON, B
DEFOSSEZ, A
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1989, 92 (2-3) : 133 - 141

← 1 2 3 4 →