CDNA CLONING OF SOMATOLACTIN, A PITUITARY PROTEIN RELATED TO GROWTH-HORMONE AND PROLACTIN

被引：184

作者：

ONO, M

TAKAYAMA, Y

RANDWEAVER, M

SAKATA, S

YASUNAGA, T

NOSO, T

KAWAUCHI, H

机构：

[1] NIPPON OIL CO LTD,CENT TECH RES LAB,NAKA KU,YOKOHAMA,KANAGAWA 231,JAPAN

[2] KITASATO UNIV,SCH FISHERIES SCI,MOLEC ENDOCRINOL LAB,IWATE 02201,JAPAN

[3] INST PHYS & CHEM RES,CTR COMPUTAT,WAKO,SAITAMA 351,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 11期

关键词：

evolution; gene family; N-terminal sequence; teleost fish;

D O I：

10.1073/pnas.87.11.4330

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

From a flounder pituitary cDNA library, cDNA clones encoding a 28-kDa glycoprotein produced by the pars intermedia of the pituitary were isolated and characterized. Nucleotide sequencing demonstrated a precursor of the 28-kDa protein, which consisted of 231 amino acid residues, to be cleaved into a signal peptide (24 amino acids) and a mature protein (207 amino acids) containing one N-glycosylation site. By comparison of amino acid sequences, the 28-kDa protein was found to be distantly and similarly related to growth hormone and prolactin. Consequently, it was named somatolactin. Somatolactin mRNAs were specifically expressed as 1.2 and 1.8 kb poly(A)+ RNAs in flounder pituitary.

引用

页码：4330 / 4334

页数：5

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