A GENE FAMILY ENCODING HETEROGENEOUS HISTONE H1 PROTEINS IN TRYPANOSOMA-CRUZI

被引：51

作者：

ASLUND, L

CARLSSON, L

HENRIKSSON, J

RYDAKER, M

TORO, GC

GALANTI, N

PETTERSSON, U

机构：

[1] BIOMED CTR,DEPT MED GENET,S-75123 UPPSALA,SWEDEN

[2] UNIV CHILE,SCH MED,DEPT CELL BIOL & GENET,SANTIAGO,CHILE

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1994年 / 65卷 / 02期

关键词：

CHROMATIN; GENE EXPRESSION; GENE ORGANIZATION; NUCLEOSOME; POLYADENYLATION; TANDEM REPEAT;

D O I：

10.1016/0166-6851(94)90082-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene family encoding a set of histone H1 proteins in Trypanosoma cruzi is described. The sequence of 3 genomic and 4 cDNA clones revealed the presence of several motifs characteristic of histone H1, although heterogeneity at the polypeptide level was evident. The clones encode histone I-Il proteins of an unusually small size (74-97 amino acids), which lack the globular domain found in histone H1 of higher eukaryotes. All histone H1 mRNAs from T. cruzi are polyadenylated, although no typical polyadenylation signal was found. Furthermore, the genes encoding the histone H1 proteins in T. cruzi are found in a tandem array containing 15-20 gene copies per haploid genome. This tandem array is located on a large chromosome of 2.2 Mb.

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页码：317 / 330

页数：14

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