PROSPECTS FOR NEW VACCINES AGAINST TUBERCULOSIS

被引：41

作者：

ORME, IM ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT MICROBIOL,MYCOBACTERIA RES LABS,FT COLLINS,CO 80523

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(00)88987-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spectacular failure of the existing bacille Calmette-Guerin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.

引用

页码：401 / 404

页数：4

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