RENAL METABOLIZING ACTIVITY STUDIED IN DOG AND MONKEY BY ISOLATED PERFUSED KIDNEY IN SITU

被引：1

作者：

BENZI, G

BERTE, F

CREMA, A

ARRIGONI, E

机构：

[1] Departments of Pharmacology, Pavia and Pisa Universities

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 08期

关键词：

Aminopyrine—renal metabolism; Kidney; perfused—dog; monkey; Oxazepam—renal metabolism; Renal metabolism—in situ determination;

D O I：

10.1002/jps.2600570804

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The drug metabolizing power of the renal tissues in an isolated in situ kidney preparation has been evaluated in the dog and monkey. Under these experimental conditions, the kidney remained connected to the other parts of the living animal, except for blood circulation which was supplied by a pump‐oxygenator system. The disappearance of the tested substances (oxazepam and aminopyrine) from extracorporeal blood was partially replaced by their metabolites. In fact, both the drugs and the metabolites were present at different concentrations in the excreted urine and in the cortical and medullar renal tissues. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1301 / &

共 20 条

[1]

BACHARACH B, 1961, S FORUM, V12, P186

[2]

BELZER SD, 1964, SURG FORUM, V15, P222

[3] INVESTIGATION OF HEPATIC DRUG METABOLISM BY ISOLATED PERFUSED LIVER IN SITU [J].