OLIGOCLONAL B-CELL LEUKEMIA CHARACTERIZED BY SPONTANEOUS CELL-DIVISION AND TELOMERE ASSOCIATION

被引：15

作者：

CROSSEN, PE ^{[1
]}

TULLY, SM ^{[1
]}

BENJES, SM ^{[1
]}

HOLLINGS, PE ^{[1
]}

BEARD, MEJ ^{[1
]}

NIMMO, JC ^{[1
]}

MORRISON, MJ ^{[1
]}

机构：

[1] CHRISTCHURCH HOSP,DEPT HEMATOL,CHRISTCHURCH,NEW ZEALAND

来源：

GENES CHROMOSOMES & CANCER | 1993年 / 8卷 / 01期

关键词：

D O I：

10.1002/gcc.2870080109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of unstimulated cultures from a female patient with chronic B-cell leukemia (CLL) revealed three cytogenetically distinct clones, suggesting that the patient's leukemia was oligoclonal. Immunoglobulin heavy chain gene rearrangement studies revealed 1 germline and 4 rearranged bands, indicative of an oligoclonal leukemic population. Further evidence of oligoclonality was provided by X-linked RFLP studies. This is the first report of oligoclonality in CLL demonstrated by cytogenetic, immunoglobulin gene rearrangement, and X-chromosome inactivation studies. In addition to oligoclonality, the patient's leukemic cells exhibited telomere association, a Robertsonian translocation, and clonal evolution, suggesting an underlying genomic instability. (C) 1993 Wiley-Liss, Inc.

引用

页码：49 / 59

页数：11

共 39 条

[1] TELOMERIC ASSOCIATIONS INVOLVING YQ12 IN A LYMPHOBLASTOID CELL-LINE [J].

ABRUZZO, MA ;

MILLER, JA ;

SINGER, VL .

CYTOGENETICS AND CELL GENETICS, 1991, 56 (3-4) :149-151

[2] CONTINUING REARRANGEMENT BUT ABSENCE OF SOMATIC HYPERMUTATION IN IMMUNOGLOBULIN GENES OF HUMAN B-CELL PRECURSOR LEUKEMIA [J].

BIRD, J ;

GALILI, N ;

LINK, M ;

STITES, D ;

SKLAR, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (01) :229-245

[3] USE OF THE X-CHROMOSOME LINKED HYPOXANTHINE PHOSPHORIBOSYL TRANSFERASE GENE AS A MARKER OF CELL MONOCLONALITY IN HEMATOPOIETIC MALIGNANCIES [J].

BROWETT, PJ ;

HOFFBRAND, AV ;

NORTON, JD .

LEUKEMIA RESEARCH, 1988, 12 (04) :321-&

[4]

CACCHIA PG, 1992, GENOMICS, V14, P70

[5] CLUSTERING OF EXTENSIVE SOMATIC MUTATIONS IN THE VARIABLE REGION OF AN IMMUNOGLOBULIN HEAVY-CHAIN GENE FROM A HUMAN B-CELL LYMPHOMA [J].

CLEARY, ML ;

MEEKER, TC ;

LEVY, S ;

LEE, E ;

TRELA, M ;

SKLAR, J ;

LEVY, R .

CELL, 1986, 44 (01) :97-106

[6]

CROCE CM, 1985, BLOOD, V65, P1

[7] CHROMOSOME-ABNORMALITIES IN CHRONIC LYMPHOCYTIC-LEUKEMIA REVEALED BY CYTOCHALASIN-B AND EPSTEIN-BARR-VIRUS [J].

CROSSEN, PE ;

GODWIN, JM ;

HEATON, DC ;

TULLY, SM .

CANCER GENETICS AND CYTOGENETICS, 1987, 28 (01) :93-100

[8] COMPLEX KARYOTYPIC EVOLUTION IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

CROSSEN, PE ;

TULLY, SM ;

MORRISON, MJ ;

HEATON, DC ;

BENJES, SM .

CANCER GENETICS AND CYTOGENETICS, 1991, 57 (02) :187-194

[9] THE TISSUE DISTRIBUTION OF THE 3-ALPHA-FUCOSYL-N-ACETYL LACTOSAMINE DETERMINANT RECOGNIZED BY THE CD15 MONOCLONAL-ANTIBODIES CMRF-7 AND CMRF-27 [J].

DAVIDSON, SE ;

MCKENZIE, JL ;

BEARD, MEJ ;

HART, DNJ .

PATHOLOGY, 1988, 20 (01) :24-31

[10] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

← 1 2 3 4 →