A GENERAL-APPROACH TOWARD THE DESIGN OF INHIBITORS OF SERINE PROTEINASES - INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY SUBSTITUTED DIHYDROURACILS

被引：13

作者：

GROUTAS, WC

HUANG, H

EPP, JB

BRUBAKER, MJ

KELLER, CE

MCCLENAHAN, JJ

机构：

[1] Department of Chemistry Wichita State University Wichita

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80431-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A general approach toward the rational design of potential inhibitors of serine proteinases is described. The approach is exemplified and validated through the use of appropriate heterocyclic systems in inhibiting human leukocyte elastase (HLE).

引用

页码：1565 / 1570

页数：6

共 13 条

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[4] C-13 NMR EVIDENCE FOR AN ENZYME-INDUCED LOSSEN REARRANGEMENT IN THE MECHANISM-BASED INACTIVATION OF ALPHA-CHYMOTRYPSIN BY 3-BENZYL-N-((METHYLSULFONYL)OXY)SUCCINIMIDE
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[8] HUMAN NEUTROPHIL ELASTASE AND ELASTASE ALPHA1-ANTIPROTEASE COMPLEX IN CYSTIC-FIBROSIS - COMPARISON WITH INTERSTITIAL LUNG-DISEASE AND EVALUATION OF THE EFFECT OF INTRAVENOUSLY ADMINISTERED ANTIBIOTIC-THERAPY
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