PREVENTION OF HUMAN-LEUKOCYTE ELASTASE-MEDIATED LUNG DAMAGE BY 3-ALKYL-4-AZETIDINONES

被引：36

作者：

HAGMANN, WK

SHAH, SK

DORN, CP

OGRADY, LA

HALE, JJ

FINKE, PE

THOMPSON, KR

BRAUSE, KA

ASHE, BM

WESTON, H

DAHLGREN, ME

MAYCOCK, AL

DELLEA, PS

HAND, KM

OSINGA, DG

BONNEY, RJ

DAVIES, P

FLETCHER, DS

DOHERTY, JB

机构：

[1] MERCK SHARP & DOHME LTD, DEPT ENZYMOL, RAHWAY, NJ 07065 USA

[2] MERCK SHARP & DOHME LTD, DEPT CELLULAR & MOLEC PHARMACOL, RAHWAY, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)80463-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Simple 3-alkyl-4-azetidinones have been previously reported as potent inhibitors of human leukocyte elastase (HLE). Further modification of these simple monocyclic beta-lactams has led to development of substituted 4-azetidinones that both inhibit HLE in a time dependent manner and, like previously reported modified cephalosporin sulfones, prevent HLE-induced lung damage in hamsters.

引用

页码：545 / 550

页数：6

共 26 条

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