CLONING OF THE CDNA-ENCODING RAT-TISSUE INHIBITOR OF METALLOPROTEINASE-1 (TIMP-1), AMINO-ACID COMPARISON WITH OTHER TIMPS, AND GENE-EXPRESSION IN RAT-TISSUES

被引：36

作者：

OKADA, A ^{[1
]}

GARNIER, JM ^{[1
]}

VICAIRE, S ^{[1
]}

BASSET, P ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,GENET MOLEC EUCARYOTES LAB,CNRS,UA 184,INSERM,F-67085 STRASBOURG,FRANCE

来源：

GENE | 1994年 / 147卷 / 02期

关键词：

WOUND HEALING; CDNA LIBRARY; EXTRACELLULAR MATRIX; TISSUE REMODELING;

D O I：

10.1016/0378-1119(94)90088-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 1 (TIMP-1) from a cDNA library derived from healing skin wounds. The deduced amino acid (aa) sequence shows 66, 35 and 34% identity with human TIMP-1 and TIMP-2, and chicken TIMP-3 aa sequences, respectively. High-level expression of rat TIMP-1 RNA was detected in the skin wounds and in normal ovary.

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页码：301 / 302

页数：2

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