EXTRAPYRAMIDAL SIDE-EFFECTS AND INCREASED SERUM PROLACTIN FOLLOWING FLUOXETINE, A NEW ANTI-DEPRESSANT

被引：171

作者：

MELTZER, HY ^{[1
]}

YOUNG, M ^{[1
]}

METZ, J ^{[1
]}

FANG, VS ^{[1
]}

SCHYVE, PM ^{[1
]}

ARORA, RC ^{[1
]}

机构：

[1] ILLINOIS STATE PSYCHIAT INST, CHICAGO, IL 60612 USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 1979年 / 45卷 / 02期

关键词：

D O I：

10.1007/BF01250091

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fluoxetine (Lilly 110140) is a potent, specific serotonin (5-HT) uptake blocker which is being tested in man for antidepressant activity. One of 9 depressed patients receiving this drug developed a dystonic reaction, parkinsonian rigidity, and increased serum prolactin levels, all signs of decreased dopaminergic activity. Homovanillic acid levels also decreased in the cerebrospinal fluid of this subject. We postulate that fluoxetine, via the increase in 5-HT activity resulting from 5-HT uptake blockade, inhibited both the nigro-striatal and tubero-infundibular dopaminergic neurons. These results provide additional evidence for a linkage between serotonergic and dopaminergic neurons in man. © 1979 Springer-Verlag.

引用

页码：165 / 175

页数：11

共 53 条

[31] EFFECTS OF MELATONIN AND SEROTONIN ON RELEASE OF FSH AND PROLACTIN [J].