KINETIC RESOLUTION OF RACEMIC ALDEHYDES BY ENANTIOSELECTIVE ALKYLATION

被引:15
作者
HAYASHI, M [1 ]
MIWATA, H [1 ]
OGUNI, N [1 ]
机构
[1] YAMAGUCHI UNIV,FAC SCI,DEPT CHEM,YAMAGUCHI 753,JAPAN
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 05期
关键词
D O I
10.1039/p19910001167
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Various types of racemic aldehydes were kinetically resolved by reaction with diethylzinc in the presence of a catalytic amount of a chiral beta-amino alcohol. Kinetic resolution of racemic chloro(phenyl)acetaldehyde gave an optically active form as an unchanged substrate, which could be converted into styrene oxide in high optical purity (97.5% ee).
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页码:1167 / 1171
页数:5
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