COMPLEMENT RECEPTORS AND PHAGOCYTOSIS

被引：186

作者：

BROWN, EJ

机构：

[1] Washington University School of Medicine, St Louis, MO

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 01期

关键词：

D O I：

10.1016/0952-7915(91)90081-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Current understanding of the molecular mechanisms involved in regulating the phagocytic function of monocytes, macrophages and polymorphonuclear leukocytes is summarized, giving emphasis to the role of the phagocyte integrins of the CD11/CD18 family. New data relating to the hypotheses that optimal function of these receptors is a property of activated cells is discussed, with reference to possible signal transduction mechanisms leading to enhanced integrin function. Finally, a model is proposed for the involvement of CD11b/CD18 in cell functions when no ligand for this receptor is apparent.

引用

页码：76 / 82

页数：7

共 46 条

[41] A MONOCLONAL-ANTIBODY TO THE ADHERENCE-PROMOTING LEUKOCYTE GLYCOPROTEIN, CD18, REDUCES ORGAN INJURY AND IMPROVES SURVIVAL FROM HEMORRHAGIC-SHOCK AND RESUSCITATION IN RABBITS [J].